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Kodi mayeso osavuta a mkodzo angazindikire matenda a Alzheimer's omwe ali kumayambiriro, ndikutsegula njira yowunikira anthu ambiri? Kafukufuku watsopano wa Frontiers in Aging Neuroscience akuwonetsa izi. Ofufuzawo adayesa gulu lalikulu la odwala a Alzheimer's okhala ndi zovuta zosiyanasiyana komanso athanzi omwe anali abwinobwino kuti adziwe kusiyana kwa zizindikiro za mkodzo.
Iwo adapeza kuti formic acid mu mkodzo ndi chizindikiro chodziwikiratu cha kuchepa kwa chidziwitso cha munthu ndipo ikhoza kuwonetsa magawo oyamba a matenda a Alzheimer. Njira zomwe zilipo zodziwira matenda a Alzheimer ndi zodula, zosasangalatsa, komanso zosavomerezeka powunika nthawi zonse. Izi zikutanthauza kuti odwala ambiri amapezeka pokhapokha ngati chithandizo chatha. Komabe, kuyesa mkodzo kosavulaza, kotsika mtengo, komanso kosavuta kwa formic acid kungakhale komwe madokotala akupempha kuti aunike msanga.
“Matenda a Alzheimer’s ndi matenda osatha komanso obisika, zomwe zikutanthauza kuti amatha kukula ndi kupitirira kwa zaka zambiri asanayambe kuoneka kuti ali ndi vuto la kuzindikira,” akutero olembawo. “Magawo oyamba a matendawa amapezeka asanafike nthawi ya matenda a dementia osasinthika, omwe ndi njira yabwino kwambiri yothandizira ndi kuchiza. Chifukwa chake, kuyezetsa matenda a Alzheimer’s kwa okalamba ndikofunikira.”
Kotero, ngati chithandizo choyambirira chili chofunikira, bwanji tilibe mapulogalamu owunikira matenda a Alzheimer's omwe ali ndi nthawi yoyambirira? Vuto lili m'njira zodziwira matenda zomwe madokotala amagwiritsa ntchito pakadali pano. Izi zikuphatikizapo positron emission tomography ya ubongo, yomwe ndi yokwera mtengo ndipo imawonetsa odwala ku radiation. Palinso mayeso a biomarker omwe amatha kuzindikira Alzheimer's, koma amafunika kutengedwa magazi kapena kubowoledwa kwa lumbar kuti apeze cerebrospinal fluid, zomwe odwala angakhale akuziletsa.
Komabe, mayeso a mkodzo savulaza anthu ambiri ndipo ndi osavuta, zomwe zimapangitsa kuti akhale abwino kwambiri powunika anthu ambiri. Ngakhale kuti ofufuza adazindikira kale zizindikiro za mkodzo za matenda a Alzheimer's, palibe chomwe chili choyenera kuzindikira magawo oyambirira a matendawa, zomwe zikutanthauza kuti njira yabwino kwambiri yothandizira matendawa ikadalipobe.
Ofufuza omwe ali kumbuyo kwa kafukufuku watsopanoyu adaphunzira kale za mankhwala achilengedwe otchedwa formaldehyde ngati chizindikiro cha mkodzo cha matenda a Alzheimer's. Komabe, pali mwayi woti matendawo azitha kuzindikirika msanga. Mu kafukufuku waposachedwapa, adayang'ana kwambiri pa formate, metabolite ya formaldehyde, kuti awone ngati ikugwira ntchito bwino ngati chizindikiro cha mkodzo.
Anthu okwana 574 adatenga nawo mbali mu kafukufukuyu, ndipo ophunzirawo anali odzipereka athanzi labwinobwino kapena anali ndi matenda osiyanasiyana, kuyambira kuchepa kwa chidziwitso mpaka kudwala kwathunthu. Ofufuzawo adasanthula zitsanzo za mkodzo ndi magazi kuchokera kwa ophunzirawo ndipo adachita kafukufuku wamaganizo.
Kafukufukuyu adapeza kuti kuchuluka kwa asidi a mkodzo kunali kwakukulu kwambiri m'magulu onse a matenda a Alzheimer ndipo kumagwirizana ndi kuchepa kwa chidziwitso poyerekeza ndi magulu athanzi, kuphatikiza gulu loyambirira la kuchepa kwa chidziwitso. Izi zikusonyeza kuti asidi wa formic akhoza kukhala chizindikiro chofunikira kwambiri pamagawo oyamba a matenda a Alzheimer.
Chochititsa chidwi n'chakuti, pamene ofufuzawo anafufuza kuchuluka kwa ma formate mkodzo pamodzi ndi zizindikiro za magazi a Alzheimer, anapeza kuti angathe kulosera molondola gawo la matenda omwe wodwala akudutsamo. Komabe, kafukufuku wowonjezereka akufunika kuti amvetsetse mgwirizano pakati pa matenda a Alzheimer ndi formic acid.
“Mkodzo wa asidi wasonyeza kuti ndi wothandiza kwambiri poyesa matenda a Alzheimer msanga,” akutero olembawo. “Kuyesa kwa mkodzo wa matenda a Alzheimer n’kosavuta komanso kotsika mtengo ndipo kuyenera kuphatikizidwa muzoyezetsa thanzi la okalamba nthawi zonse.”
Wang, Y. et al. (2022) Kuwunikanso mwadongosolo kwa asidi wa mkodzo ngati chizindikiro chatsopano cha matenda a Alzheimer's. Malire mu neurobiology ya ukalamba. doi.org/10.3389/fnagi.2022.1046066.
Ma tag: ukalamba, matenda a Alzheimer, zizindikiro, magazi, ubongo, matenda osatha, mankhwala, matenda a dementia, matenda, madokotala, formaldehyde, neurology, positron emission tomography, kafukufuku, tomography, urinalysis
Ku Pittcon 2023 ku Philadelphia, Pennsylvania, tinakambirana ndi Pulofesa Joseph Wang, wopambana mphoto ya Ralph N. Adams mu Analytical Chemistry chaka chino, za kusinthasintha kwa ukadaulo wa biosensor.
Mu kuyankhulana uku, tikambirana za biopsy yokhudza kupuma ndi momwe ingakhalire chida chothandiza pophunzira zizindikiro za matenda kuti tipeze matenda msanga ndi Mariana Leal, Mtsogoleri wa Gulu ku Owlstone Medical.
Monga gawo la ndemanga yathu ya SLAS US 2023, tikukambirana za labu yamtsogolo ndi momwe ingawonekere ndi Luigi Da Via, Mtsogoleri wa Gulu Lotsogolera Mayeso a GSK.
News-Medical.Net imapereka chithandizo ichi chamankhwala motsatira malamulo ndi zikhalidwe izi. Chonde dziwani kuti chidziwitso chachipatala chomwe chili patsamba lino cholinga chake ndi kuthandiza, osati kulowa m'malo, ubale wa dokotala/dokotala wa wodwalayo komanso upangiri wachipatala womwe angapereke.