Potsatira malangizo okhwima okhudza nkhani posankha magwero, timangolumikiza ku mabungwe ofufuza zamaphunziro, malo odziwika bwino ofalitsa nkhani, ndipo, ngati alipo, maphunziro azachipatala owunikidwa ndi anzawo. Dziwani kuti manambala omwe ali m'mabulaketi (1, 2, ndi zina zotero) ndi maulalo oti muwatsitse ku maphunzirowa.
Chidziwitso chomwe chili m'nkhani zathu sichinapangidwe kuti chilowe m'malo mwa kulankhulana ndi katswiri wazachipatala wodziwa bwino ntchito ndipo sichinapangidwe kuti chigwiritsidwe ntchito ngati upangiri wachipatala.
Nkhaniyi yachokera pa umboni wa sayansi, wolembedwa ndi akatswiri ndipo waunikidwanso ndi gulu lathu lophunzitsidwa bwino la olemba nkhani. Dziwani kuti manambala omwe ali m'mabokosi (1, 2, ndi zina zotero) akuyimira maulalo oti muwatsitse ku maphunziro azachipatala omwe amawunikidwa ndi anzawo.
Gulu lathu likuphatikizapo akatswiri olembetsa zakudya ndi akatswiri azakudya, aphunzitsi azaumoyo ovomerezeka, komanso akatswiri odziwa bwino ntchito zolimbitsa thupi, aphunzitsi aumwini ndi akatswiri ochita masewera olimbitsa thupi. Cholinga cha gulu lathu si kufufuza mokwanira kokha, komanso kusachita zinthu mopitirira muyeso komanso mopanda tsankho.
Chidziwitso chomwe chili m'nkhani zathu sichinapangidwe kuti chilowe m'malo mwa kulankhulana ndi katswiri wazachipatala wodziwa bwino ntchito ndipo sichinapangidwe kuti chigwiritsidwe ntchito ngati upangiri wachipatala.
Chimodzi mwa zowonjezera zomwe zimagwiritsidwa ntchito kwambiri m'mankhwala ndi zowonjezera masiku ano ndi magnesium stearate. Ndipotu, zidzakhala zovuta kupeza zowonjezera pamsika masiku ano zomwe zilibe - kaya tikulankhula za zowonjezera za magnesium, ma enzymes ogaya chakudya, kapena zowonjezera zina zomwe mungasankhe - ngakhale simungawone dzina lake mwachindunji.
Kawirikawiri imatchedwa ndi mayina ena monga "vegetable stearate" kapena zochokera kuzinthu zina monga "stearic acid", imapezeka pafupifupi kulikonse. Kuwonjezera pa kukhala paliponse, magnesium stearate ndi imodzi mwa zosakaniza zomwe zimakangana kwambiri padziko lonse lapansi.
M'njira zina, izi zikufanana ndi mkangano wokhudza vitamini B17: kodi ndi poizoni kapena mankhwala a khansa? Tsoka ilo kwa anthu, akatswiri azaumoyo wachilengedwe, ofufuza amakampani othandizira, ndi akatswiri azachipatala nthawi zambiri amapereka umboni wotsutsana kuti athandizire malingaliro awo, ndipo zoona zake n'zovuta kuzipeza.
Ndi bwino kutenga njira yothandiza pa zokambirana zotere ndikusamala kuti musatenge mbali ndi malingaliro okhwima.
Mfundo yaikulu ndi iyi: Monga ma filler ambiri ndi ma bulking agents, magnesium stearate si yabwino pa mlingo waukulu, koma kuidya sikoopsa monga momwe ena amanenera chifukwa nthawi zambiri imapezeka pa mlingo wochepa kwambiri.
Magnesium stearate ndi mchere wa magnesium wa stearic acid. Kwenikweni, ndi mankhwala okhala ndi mitundu iwiri ya stearic acid ndi magnesium.
Stearic acid ndi mafuta okhuta omwe amapezeka muzakudya zambiri, kuphatikizapo mafuta a nyama ndi ndiwo zamasamba ndi mafuta. Cocoa ndi flaxseed ndi zitsanzo za zakudya zomwe zili ndi stearic acid yambiri.
Pambuyo poti magnesium stearate yagawidwanso m'zigawo zake m'thupi, mafuta ake amakhala ofanana ndi stearic acid. Ufa wa magnesium stearate umagwiritsidwa ntchito kwambiri ngati chowonjezera pazakudya, gwero la chakudya komanso chowonjezera mu zodzoladzola.
Magnesium stearate ndiye chinthu chomwe chimagwiritsidwa ntchito kwambiri popanga mapiritsi chifukwa ndi mafuta othandiza kwambiri. Amagwiritsidwanso ntchito mu makapisozi, ufa, ndi zakudya zambiri, kuphatikizapo maswiti ambiri, ma gummies, zitsamba, zonunkhira, ndi zosakaniza zophikira.
Chodziwika kuti "chothandizira kuyenda," chimathandiza kufulumizitsa ntchito yopanga mwa kuletsa zosakaniza kuti zisamamatire ku zida zamakanika. Chisakanizo cha ufa chomwe chimaphimba pafupifupi mankhwala aliwonse kapena zowonjezera ndi pang'ono chabe.
Ingagwiritsidwenso ntchito ngati emulsifier, guluu, chokhuthala, choletsa kukhetsa, mafuta odzola, chotulutsa ndi chochotsera poizoni.
Sikuti imangothandiza popanga zinthu mwa kulola kuti makina omwe amawapanga aziyenda bwino, komanso imapangitsa kuti mapiritsiwo azisavuta kumeza ndikudutsa m'mimba. Magnesium stearate ndi chinthu chodziwika bwino chomwe chimagwiritsidwa ntchito pochiza matenda osiyanasiyana komanso chimalimbikitsa kuyamwa ndi kusungunuka kwa mankhwala.
Ena amanena kuti amatha kupanga mankhwala kapena zowonjezera popanda zinthu zina monga magnesium stearate, zomwe zimapangitsa funso lakuti n’chifukwa chiyani amagwiritsidwa ntchito pamene pali njira zina zachilengedwe. Koma izi sizingakhale choncho.
Mankhwala ena tsopano apangidwa ndi njira zina m'malo mwa magnesium stearate pogwiritsa ntchito zinthu zachilengedwe monga ascorbyl palmitate, koma timachita izi pamene zili zomveka osati chifukwa chakuti talakwitsa sayansi. Komabe, njira zina izi sizigwira ntchito nthawi zonse chifukwa zimakhala ndi makhalidwe osiyanasiyana.
Pakadali pano sizikudziwika ngati kusintha kwa magnesium stearate n'kotheka kapena n'kofunikira.
Magnesium stearate mwina ndi yotetezeka ikagwiritsidwa ntchito mu zakudya zowonjezera komanso zakudya zina. Ndipotu, kaya mukudziwa kapena ayi, mwina mumawonjezera mavitamini ambiri, mafuta a kokonati, mazira ndi nsomba tsiku lililonse.
Monga mchere wina wa chelated (magnesium ascorbate, magnesium citrate, ndi zina zotero), [i]libe zotsatirapo zoyipa chifukwa imapangidwa ndi mchere ndi ma acids azakudya (vegetable stearic acid yosakanizidwa ndi mchere wa magnesium). Ili ndi zinthu zokhazikika zosalowerera.
Kumbali ina, bungwe la National Institutes of Health (NIH) mu lipoti lake lonena za magnesium stearate linachenjeza kuti magnesium yochulukirapo ikhoza kusokoneza kufalikira kwa mitsempha ya mitsempha ndikutsogolera kufooka ndi kuchepa kwa mphamvu zamagetsi. Ngakhale izi sizichitika kawirikawiri, bungwe la National Institutes of Health (NIH) linati:
Matenda ambirimbiri amapezeka chaka chilichonse, koma zizindikiro zake zimakhala zochepa. Kuopsa kwambiri kumachitika nthawi zambiri munthu akapatsidwa mankhwala kudzera m'mitsempha kwa maola ambiri (nthawi zambiri amakhala ndi preeclampsia) ndipo kungachitike munthu akalandira mankhwala mopitirira muyeso kwa nthawi yayitali, makamaka pamene impso zake zikulephera kugwira ntchito. Kuopsa kwambiri kwanenedwa kuti munthu akalandira mankhwalawo mwachangu, koma ndi kochepa kwambiri.
Komabe, lipotilo silinatsimikizire aliyense. Kungoyang'ana mwachidule pa Google kukuwonetsani kuti magnesium stearate imagwirizana ndi zotsatirapo zambiri, monga:
Popeza imakonda madzi (“imakonda madzi”), pali malipoti akuti magnesium stearate ingachepetse kuchuluka kwa mankhwala ndi zowonjezera m'mimba. Mphamvu zoteteza za magnesium stearate zimakhudza mwachindunji mphamvu ya thupi yoyamwa mankhwala ndi michere, zomwe zimapangitsa kuti mankhwala kapena zowonjezerazo zikhale zopanda ntchito ngati thupi silingathe kuziphwanya bwino.
Kumbali inayi, kafukufuku wochitidwa ndi University of Maryland akuti magnesium stearate sikhudza kuchuluka kwa mankhwala omwe amatulutsidwa ndi propranolol hydrochloride, mankhwala omwe amagwiritsidwa ntchito poletsa kugunda kwa mtima ndi bronchospasm, kotero oweruza akadali kunja pakadali pano.
Ndipotu, opanga amagwiritsa ntchito magnesium stearate kuti awonjezere kusinthasintha kwa makapisozi ndikulimbikitsa kuyamwa bwino kwa mankhwalawa pochedwetsa kusweka kwa zomwe zili mkati mpaka zitafika m'matumbo.
Maselo a T, omwe ndi gawo lofunika kwambiri la chitetezo cha mthupi chomwe chimalimbana ndi tizilombo toyambitsa matenda, sakhudzidwa mwachindunji ndi magnesium stearate, koma amakhudzidwa ndi stearic acid, yomwe ndi gawo lalikulu la zinthu zogwiritsidwa ntchito limodzi.
Inafotokozedwa koyamba mu 1990 mu magazini ya Immunology, komwe kafukufuku wofunika kwambiriyu adawonetsa momwe mayankho a chitetezo chamthupi omwe amadalira T amalepheretsedwera pamaso pa stearic acid yokha.
Mu kafukufuku wa ku Japan wofufuza zinthu zomwe zimagwiritsidwa ntchito pochiza matenda a shuga, magnesium stearate ya masamba inapezeka kuti imayambitsa kupanga formaldehyde. Komabe, izi sizingakhale zoopsa monga momwe zikuonekera, chifukwa umboni ukusonyeza kuti formaldehyde imapezeka mwachibadwa mu zipatso zambiri zatsopano, ndiwo zamasamba ndi zinthu zopangidwa ndi nyama, kuphatikizapo maapulo, nthochi, sipinachi, kale, ng'ombe komanso khofi.
Kuti muchepetse nkhawa zanu, magnesium stearate imapanga formaldehyde yochepa kwambiri kuposa ma filler onse omwe ayesedwa: 0.3 nanograms pa gramu imodzi ya magnesium stearate. Poyerekeza, kudya bowa wouma wa shiitake kumapanga mamiligalamu oposa 406 a formaldehyde pa kilogalamu imodzi yomwe mudya.
Mu 2011, bungwe la World Health Organization linafalitsa lipoti lofotokoza momwe magulu angapo a magnesium stearate adaipitsidwa ndi mankhwala omwe angakhale oopsa, kuphatikizapo bisphenol A, calcium hydroxide, dibenzoylmethane, irganox 1010 ndi zeolite (sodium aluminium silicate).
Popeza izi ndi nkhani yokhayokha, sitinganene msanga kuti anthu omwe akumwa mankhwala owonjezera komanso mankhwala okhala ndi magnesium stearate ayenera kusamala ndi poizoni.
Anthu ena akhoza kukhala ndi zizindikiro za ziwengo akamadya zinthu kapena zowonjezera zomwe zili ndi magnesium stearate, zomwe zingayambitse kutsegula m'mimba komanso kupweteka m'mimba. Ngati muli ndi zotsatirapo zoyipa chifukwa cha zowonjezera, muyenera kuwerenga mosamala zilembo za zosakanizazo ndikuchita kafukufuku pang'ono kuti mupeze zinthu zomwe sizipangidwa ndi zowonjezera zodziwika bwino.
Bungwe la National Center for Biotechnology limalimbikitsa kuti mlingo wa 2500 mg wa magnesium stearate pa kilogalamu imodzi ya kulemera kwa thupi ukhale wotetezeka. Kwa munthu wamkulu wolemera makilogalamu pafupifupi 150, izi zikufanana ndi mamiligalamu 170,000 patsiku.
Poganizira za zotsatirapo zoyipa za magnesium stearate, ndikofunikira kuganizira za "kudalira mlingo". Mwanjira ina, kupatula kumwa mankhwala ochulukirapo m'mitsempha pa matenda akuluakulu, kuvulaza kwa magnesium stearate kwawonetsedwa kokha mu kafukufuku wa labotale pomwe makoswe adakakamizidwa kumwa mankhwala ochulukirapo kotero kuti palibe munthu padziko lapansi amene akanatha kudya mankhwala ambiri chonchi.
Mu 1980, magazini ya Toxicology inanena za zotsatira za kafukufuku pomwe mbewa 40 zinadyetsedwa zakudya zopangidwa ndi theka zomwe zili ndi 0%, 5%, 10%, kapena 20% ya magnesium stearate kwa miyezi itatu. Izi ndi zomwe adapeza:
Dziwani kuti kuchuluka kwa stearic acid ndi magnesium stearate zomwe zimagwiritsidwa ntchito kwambiri m'mapiritsi ndi kochepa. Stearic acid nthawi zambiri amapanga 0.5–10% polemera piritsi, pomwe magnesium stearate nthawi zambiri amapanga 0.25–1.5% polemera piritsi. Chifukwa chake, piritsi la 500 mg likhoza kukhala ndi pafupifupi 25 mg ya stearic acid ndi pafupifupi 5 mg ya magnesium stearate.
Kuchuluka kwa chinthu chilichonse kungakhale koopsa ndipo anthu amatha kufa chifukwa chomwa madzi ambiri, sichoncho? Izi ndizofunikira kukumbukira chifukwa kuti magnesium stearate ivulaze munthu, amafunika kumwa makapisozi/mapiritsi masauzande ambiri patsiku.