Palibe mankhwala a matenda a Alzheimer, koma asayansi nthawi zonse amafufuza njira zochizira zizindikiro za matendawa.
Ofufuza akuyesetsanso kupeza msanga matenda a dementia okhudzana ndi matenda a Alzheimer, chifukwa kuwapeza msanga kungathandize pa chithandizo.
Malinga ndi kafukufuku watsopano wofalitsidwa mu Frontiers in Aging Neuroscience, asidi wa formic mu mkodzo akhoza kukhala chizindikiro cha matenda a Alzheimer's.
Bungwe la US Centers for Disease Control and Prevention (CDC) limafotokoza matenda a dementia ngati “kulephera kukumbukira, kuganiza, kapena kupanga zisankho komwe kumasokoneza zochita za tsiku ndi tsiku.”
Kuwonjezera pa matenda a Alzheimer's, palinso mitundu ina ya matenda a dementia monga matenda a dementia okhala ndi matupi a Lewy ndi matenda a vascular dementia. Koma matenda a Alzheimer's ndi omwe amapezeka kwambiri m'thupi la dementia.
Malinga ndi lipoti la 2022 la Alzheimer's Disease Association, anthu pafupifupi 6.5 miliyoni ku United States akukhala ndi matendawa. Kuphatikiza apo, ofufuza akuyembekeza kuti chiwerengerochi chidzawirikiza kawiri pofika chaka cha 2050.
Kuphatikiza apo, anthu omwe ali ndi matenda a Alzheimer's omwe akukula kwambiri akhoza kukhala ndi vuto lomeza, kulankhula, komanso kuyenda.
Mpaka kumayambiriro kwa zaka za m'ma 2000, njira yokhayo yodziwira ngati munthu ali ndi matenda a Alzheimer's kapena mtundu wina wa dementia inali yochitidwa opaleshoni.
Malinga ndi bungwe la National Institute on Aging, madokotala tsopano amatha kuchita opaleshoni yoboola lumbar, yomwe imadziwikanso kuti opaleshoni yoboola lumbar, kuti aone ngati pali zizindikiro zokhudzana ndi matenda a Alzheimer's.
Madokotala amafufuza zizindikiro monga beta-amyloid 42, yomwe ndi gawo lalikulu la ma amyloid plaques muubongo, ndipo angayang'ane zolakwika pa PET scan.
"Njira zatsopano zojambulira zithunzi, makamaka zithunzi za amyloid, zithunzi za amyloid PET, ndi zithunzi za tau PET, zimatithandiza kuona zinthu zosazolowereka muubongo munthu akadali moyo," anatero pulofesa wazaumoyo komanso dokotala wa ku University of Michigan Kenneth M. Dr. Langa. ku Ann Arbor, yemwe sanachite nawo kafukufukuyu, adapereka ndemanga pa pulogalamu yaposachedwa ya Michigan Medicine.
Njira zina zochiritsira zingathandize kuchepetsa kuopsa kwa zizindikiro za mphumu ndikuchepetsa kukula kwa matendawa, ngakhale kuti sizingathe kuchiza.
Mwachitsanzo, dokotala angapereke mankhwala monga donepezil kapena galantamine kuti achepetse zizindikiro za mphumu. Mankhwala ofufuza otchedwa lecanemab angathandizenso kuchepetsa kufalikira kwa matenda a Alzheimer's.
Popeza kuyezetsa matenda a Alzheimer's n'kokwera mtengo ndipo sikungapezeke kwa aliyense, ofufuza ena akuika patsogolo kuyezetsa matenda msanga.
Ofufuza ochokera ku Shanghai Jiaotong University ndi WuXi Institute of Diagnostic Innovation of China adasanthula pamodzi ntchito ya formic acid monga chizindikiro cha matenda a Alzheimer's mu mkodzo.
Asayansi anasankha mankhwala amenewa potengera kafukufuku wakale wa matenda a Alzheimer's. Iwo aona kuti kagayidwe kabwino ka formaldehyde ndi chizindikiro chachikulu cha kuwonongeka kwa chidziwitso chokhudzana ndi ukalamba.
Pa kafukufukuyu, olembawo adalemba anthu 574 ochokera ku Memory Clinic of the Sixth People's Hospital of Shanghai, China.
Anagawa ophunzirawo m'magulu asanu kutengera momwe adachitira pa mayeso a ntchito ya ubongo; magulu awa anali kuyambira pa kuzindikira bwino mpaka matenda a Alzheimer's:
Ofufuzawo adasonkhanitsa zitsanzo za mkodzo kuchokera kwa ophunzirawo kuti akawone kuchuluka kwa asidi wa formic ndi zitsanzo za magazi kuti akawunike DNA.
Poyerekeza kuchuluka kwa asidi a formic m'gulu lililonse, ofufuza adapeza kusiyana pakati pa ophunzira omwe ali ndi thanzi labwino komanso omwe ali ndi vuto la kuzindikira pang'ono.
M'magulu omwe ali ndi kuchepa kwa chidziwitso, kuchuluka kwa formic acid mu mkodzo kunali kwakukulu kuposa m'magulu omwe ali ndi ntchito zabwino za chidziwitso.
Kuphatikiza apo, omwe adadwala matenda a Alzheimer's anali ndi asidi wambiri wa formic mu mkodzo wawo kuposa omwe adadwala matenda amisala.
Asayansiwa adapezanso mgwirizano woipa pakati pa kuchuluka kwa formic acid mu mkodzo ndi mayeso a ubongo m'malo okumbukira ndi kusamala.
"UA idakwera kwambiri mu gulu la matenda [lomwe linkadziwika kuti ndi losazindikira bwino], zomwe zikutanthauza kuti UA ingagwiritsidwe ntchito pozindikira matenda a Alzheimer's msanga," olembawo adalemba.
Zotsatira za kafukufukuyu ndizofunikira pazifukwa zingapo, kuphatikizapo mtengo wokwera wopezera matenda a Alzheimer's.
Ngati kafukufuku wina akusonyeza kuti kapangidwe ka mkodzo kangathe kuzindikira kuchepa kwa chidziwitso, izi zitha kukhala mayeso osavuta kugwiritsa ntchito komanso otsika mtengo.
Kuphatikiza apo, ngati mayeso oterewa angapeze kuchepa kwa chidziwitso komwe kumakhudzana ndi matenda a Alzheimer's, akatswiri azaumoyo amatha kulowererapo mwachangu.
Dr. Sandra Petersen, DNP, wachiwiri kwa purezidenti wamkulu wa zaumoyo ku Pegasus Senior Living, adauza Medical News Today za kafukufukuyu:
"Kusintha kwa matenda a Alzheimer kumayamba pafupifupi zaka 20 mpaka 30 munthu asanazindikire matendawa ndipo nthawi zambiri kumakhala kosaonekera mpaka kuwonongeka kwakukulu kutakhalapo. Tikudziwa kuti kuzindikira msanga kungapangitse odwala kupeza njira zambiri zochiritsira komanso kukonzekera chisamaliro chamtsogolo."
"Kupambana pa mayeso otere (osavulaza komanso otsika mtengo) omwe akupezeka kwa anthu onse kungathandize kwambiri polimbana ndi matenda a Alzheimer," adatero Dr. Peterson.
Posachedwapa asayansi apeza njira yodziwira matenda a Alzheimer yomwe ingathandize madokotala kuzindikira matenda a Alzheimer's msanga. Izi zithandiza madokotala…
Zomwe zapezeka mu mbewa tsiku lina zingathandize kupanga mayeso a magazi omwe adzakhala gawo la kuyezetsa magazi kwa Alzheimer's ndi mitundu ina ya matenda amisala ...
Kafukufuku watsopano amagwiritsa ntchito ma PET brain scans kuti alosere kuchepa kwa chidziwitso kutengera kupezeka kwa mapuloteni a amyloid ndi tau muubongo, pakati pa zinthu zina zokhudzana ndi chidziwitso…
Madokotala pakadali pano amagwiritsa ntchito mayeso osiyanasiyana a ubongo ndi ma scan kuti adziwe matenda a Alzheimer's. Ofufuza apanga njira yogwiritsira ntchito yomwe ingagwiritsidwe ntchito pa munthu m'modzi…
Kuyezetsa maso mwachangu tsiku lina kungapereke chidziwitso chofunikira chokhudza thanzi la ubongo. Makamaka, kungathe kuzindikira zizindikiro za matenda a dementia.