Palibe mankhwala a matenda a Alzheimer, koma asayansi nthawi zonse amafufuza njira zochizira zizindikiro za matendawa.
Ofufuza akuyesetsanso kupeza msanga matenda a dementia okhudzana ndi matenda a Alzheimer, chifukwa kuwapeza msanga kungathandize pa chithandizo.
Kafukufuku watsopano wofalitsidwa mu Frontiers in Aging Neuroscience akusonyeza kuti uroformic acid ikhoza kukhala chizindikiro cha matenda a Alzheimer's.
Bungwe la US Centers for Disease Control and Prevention (CDC) limafotokoza matenda a dementia ngati “kulephera kukumbukira, kuganiza, kapena kupanga zisankho zomwe zimasokoneza zochita za tsiku ndi tsiku.”
Kuwonjezera pa matenda a Alzheimer's, palinso mitundu ina ya matenda a dementia monga matenda a dementia okhala ndi matupi a Lewy ndi matenda a vascular dementia. Koma matenda a Alzheimer's ndi omwe amapezeka kwambiri m'thupi la dementia.
Malinga ndi lipoti la 2022 la Alzheimer's Disease Association, anthu pafupifupi 6.5 miliyoni ku United States akukhala ndi matendawa. Kuphatikiza apo, ofufuza akuyembekeza kuti chiwerengerochi chidzawirikiza kawiri pofika chaka cha 2050.
Kuphatikiza apo, anthu omwe ali ndi matenda a Alzheimer's omwe akukula kwambiri akhoza kukhala ndi vuto lomeza, kulankhula, komanso kuyenda.
Mpaka kumayambiriro kwa zaka za m'ma 2000, njira yokhayo yodziwira ngati munthu ali ndi matenda a Alzheimer's kapena mtundu wina wa dementia inali yochitidwa opaleshoni.
Malinga ndi bungwe la National Institute on Aging, madokotala tsopano amatha kuchita opaleshoni yoboola lumbar, yomwe imadziwikanso kuti opaleshoni yoboola lumbar, kuti aone ngati pali zizindikiro zokhudzana ndi matenda a Alzheimer's.
Madokotala amafufuza zizindikiro monga beta-amyloid 42 (gawo lalikulu la ma amyloid plaques muubongo) ndipo angayang'ane zolakwika pa PET scan.
“Njira zatsopano zojambulira zithunzi, makamaka kujambula zithunzi za amyloid, kujambula zithunzi za PET amyloid, ndi kujambula zithunzi za tau PET, zimatithandiza kuona zinthu zosazolowereka muubongo pamene munthu ali moyo,” anatero pulofesa wa zaumoyo wa anthu ku Michigan komanso dokotala Kenneth M., Dr. Langa. Mu Ann Arbor, yemwe sanali nawo mu kafukufukuyu, adapereka ndemanga pa podcast yaposachedwa ya Michigan Medicine.
Pali njira zingapo zochiritsira zomwe zingathandize kuchepetsa kuopsa kwa zizindikiro za mphumu ndikuchepetsa kukula kwa matendawa, ngakhale kuti sangathe kuchiza.
Mwachitsanzo, dokotala angapereke mankhwala monga donepezil kapena galantamine kuti achepetse zizindikiro za mphumu. Mankhwala ofufuza otchedwa lecanemab angathandizenso kuchepetsa kufalikira kwa matenda a Alzheimer's.
Popeza kuyezetsa matenda a Alzheimer's n'kokwera mtengo ndipo sikungapezeke kwa aliyense, ofufuza ena akuika patsogolo kuyezetsa matenda msanga.
Ofufuza ochokera ku Shanghai Jiao Tong University ndi Wuxi Institute of Diagnostic Innovation ku China adasanthula pamodzi ntchito ya formic acid monga chizindikiro cha matenda a Alzheimer's mu mkodzo.
Asayansiwa adasankha chinthu ichi potengera kafukufuku wawo wakale pa zizindikiro za matenda a Alzheimer's. Amanena kuti formaldehyde metabolism yosazolowereka ndi chizindikiro chachikulu cha kuwonongeka kwa chidziwitso chokhudzana ndi ukalamba.
Pa kafukufukuyu, olembawo adalemba anthu 574 ochokera ku Memory Clinic of the Sixth People's Hospital of Shanghai, China.
Anagawa ophunzirawo m'magulu asanu kutengera momwe adachitira pa mayeso a ntchito ya ubongo; magulu awa anali kuyambira pa kuzindikira bwino mpaka pa matenda a Alzheimer's:
Ofufuzawo adasonkhanitsa zitsanzo za mkodzo kuchokera kwa ophunzirawo kuti akawone kuchuluka kwa asidi wa formic ndi zitsanzo za magazi kuti akawunike DNA.
Poyerekeza kuchuluka kwa asidi a formic m'gulu lililonse, ofufuzawo adaphunzira kuti panali kusiyana pakati pa omwe ali ndi thanzi labwino komanso omwe anali ndi vuto pang'ono.
Gulu lomwe linali ndi vuto la kuzindikira pang'ono linali ndi asidi wambiri mu mkodzo kuposa gulu lomwe linali ndi thanzi labwino.
Kuphatikiza apo, omwe adadwala matenda a Alzheimer's anali ndi asidi wambiri wa formic mu mkodzo wawo kuposa omwe adadwala matenda amisala.
Asayansiwa adapezanso kuti kuchuluka kwa asidi a mkodzo kunali kogwirizana ndi mayeso a ubongo pakukumbukira ndi kusamala.
"Milingo ya asidi ya mkodzo inali yokwera kwambiri mu gulu la matenda [lomwe limatchedwa kuti kuchepa kwa chidziwitso cha munthu], zomwe zikutanthauza kuti asidi ya mkodzo ingagwiritsidwe ntchito pozindikira matenda a Alzheimer's msanga," olembawo akulemba.
Zotsatira za kafukufukuyu ndizofunikira pazifukwa zingapo, kuphatikizapo mtengo wokwera wopezera matenda a Alzheimer's.
Ngati kafukufuku wina akusonyeza kuti uric acid imatha kuzindikira kuchepa kwa chidziwitso, izi zitha kukhala mayeso osavuta kugwiritsa ntchito komanso otsika mtengo.
Kuphatikiza apo, ngati mayeso oterewa angapeze kuchepa kwa chidziwitso komwe kumakhudzana ndi matenda a Alzheimer's, akatswiri azaumoyo amatha kulowererapo mwachangu.
Dr. Sandra Petersen, DNP, wachiwiri kwa purezidenti wamkulu wa zaumoyo ku Pegasus Senior Living, adalankhula za kafukufukuyu poyankhulana ndi Medical News Today:
"Kusintha kwa matenda a Alzheimer kumayamba pafupifupi zaka 20 mpaka 30 munthu asanazindikire matendawa ndipo nthawi zambiri kumakhala kosaonekera mpaka kuwonongeka kwakukulu kutakhalapo. Tikudziwa kuti kuzindikira msanga kungapatse odwala njira zambiri zochiritsira komanso kuthekera kokonzekera chisamaliro chamtsogolo."
"Kupita patsogolo kwa mayeso awa (osavulaza komanso otsika mtengo) omwe alipo kwa anthu onse kudzasintha kwambiri polimbana ndi matenda a Alzheimer," adatero Dr. Peterson.
Posachedwapa asayansi apeza njira yodziwira matenda a Alzheimer yomwe ingathandize madokotala kuzindikira matenda a Alzheimer's posachedwa. Izi zithandiza madokotala…
Zotsatira za kafukufuku watsopano mu mbewa tsiku lina zingathandize kupanga mayeso a magazi omwe adzakhala gawo la kuyezetsa magazi kwa Alzheimer's ndi mitundu ina ya…
Kafukufuku watsopano amagwiritsa ntchito ma PET brain scans kuti alosere kuchepa kwa chidziwitso kutengera kupezeka kwa mapuloteni a amyloid ndi tau muubongo, apo ayi chidziwitso…
Madokotala pakadali pano amagwiritsa ntchito mayeso osiyanasiyana a ubongo ndi ma scan kuti adziwe matenda a Alzheimer's. Ofufuza apanga njira yogwiritsira ntchito yomwe ingagwiritsidwe ntchito pa munthu m'modzi…
Kuyezetsa maso mwachangu tsiku lina kungapereke chidziwitso chofunikira chokhudza thanzi la ubongo. Makamaka, kungathe kuzindikira zizindikiro za matenda a dementia.